Coagulant activity of recombinant human factor VII produced by lentiviral human F7 gene transfer in immortalized hepatocyte-like cell line

Establishment of a clonal immortalized human mesenchymal stem cell line expressing hTERT using lentiviral gene transfer

P-128: Optimization of Human LH Gene Expression by Codon Usage Adaptation in CHO Cell Line

a:4:{s:10:"Background";s:897:"Human luteinizing hormone (hLH) belongs to glycoprotein hormones which is composed of two non-covalently linked subunit, α and β. The α-subunit is similar in all glycoprotein hormones, whereas the β-subunit is conferring the hormonal specificity. This hormone has important roles in the growth and maturity of sexual organs and secondary sexual characteristics and st...

کلونینگ cDNA فاکتور VII انعقادی حاصل از رده سلولی هپاتوما

Abstract Background: Factor VII, is a coagulant protease it begins the proteolytic cascade reactions and produces thrombin. The use of recombinant human factor VII, (rhFVII) is effective for the treatment of patients with hemophilia A or B. It is a target for gene therapy. This study was done to clone factor VII from HepG2 cell line. Methods: RNA was extracted from the hepatoma, (HepG2), ...

Optimization and Construction of Human Insulin-like Growth Factor 1 Gene related to human health

Background and aims: Laron syndrome is a disease that treated by Insulin-like Growth Factor 1 (IGF-1). This protein is a single chain and has three disulfide bonds. People with Laron syndrome have low rates of cancer and diabetes, although they appear to be at increased risk of casual death due to their stature. IGF-1 is synthesized by many tissues and is secreted from liver as an endocrine hor...

The influence of dietary fat on postprandial lipaemia and factor VII coagulant activity in human subjects.

Factor VII coagulant activity (FVIIc) is a potent risk factor for heart disease. The Northwick Park Heart Study (NPHS) found that elevated levels of FVIIc are associated with increased risk of fatal IHD, particularly in men over the age of 55 years and this association was stronger than that for plasma cholesterol (Meade et al. 1986). Subsequent studies have confirmed this association (Meade et...